Synthesis of N-Aryl-2-(1', 6'-dihydro-6'-pyridazinone-3'-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds

Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (2): 172-176.

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Synthesis of N-Aryl-2-(1', 6'-dihydro-6'-pyridazinone-3'-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds

WANG Duo-zhi¹, CAO Ling-hua^1,2

1. Department of Chemistry, Xinjiang University, Urumqi 830046, P. R. China;
2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2004-03-04 Online:2005-03-24 Published:2011-07-27
Supported by:
Supported by the National Natural Science Foundation of China (Nos.29962002 and 20462006).

Abstract

Abstract: 1,6-Dihydro-3-hydrozinocarbonyl-6-pyridazinone(compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate.A series of N-aryl-2-(1',6'-dihydro-6'-pyridazinone-3'-earbonyl) thiosemicarbazides 3a-3f were synthesized from the reaction of aryl isothiocyanates with compound 2.The terminal compounds 1,3, 4-thiadiazole, 1,3,4-oxadiazole and 1,2, 4-triazol-5-thione derivatives were cyclized from compounds 3a_3f.Their structures were confirmed by IR, ¹H NMR, MS and elemental analyses.

Key words: Pyridazinone, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole, 1,2,4-Triazol-5-thione, Synthesis

WANG Duo-zhi, CAO Ling-hua. Synthesis of N-Aryl-2-(1', 6'-dihydro-6'-pyridazinone-3'-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds[J]. Chemical Research in Chinese Universities, 2005, 21(2): 172-176.

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Synthesis of N-Aryl-2-(1', 6'-dihydro-6'-pyridazinone-3'-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds

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