Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (2): 178-185.

• Articles • Previous Articles     Next Articles

Synthesis of Conformationally Locked 2'-Deoxy-2'-nucleobase-5'- Isonucleosides: 2'-Deoxy-2'-nucleobase-5'deoxy-1', 4':3', 6'-dianhydro-D-mannitol

TIAN Xiao-bing1, ZHANG Ling1, MIN Ji-mei1, ZHANG Li-he1, LU Yang2, JIANG Reng-wang2, ZHENG Qi-tai2   

  1. 1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China;
    2. Institute of Materia Medica, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100050, P. R. China
  • Received:2000-05-01 Online:2001-04-24 Published:2011-08-04
  • Supported by:

    Supported by the National Natural Science Foundation of China

Abstract: Novel bicyclic isonucleosides, 2'-deoxy- 2'-nucleobase- 5'-deoxy- 1', 4': 3', 6'-dianhydro D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con formation.

Key words: Bicyclic isonucleoside, Locked conformation, Synthesis