Chemical Research in Chinese Universities ›› 2024, Vol. 40 ›› Issue (5): 776-785.doi: 10.1007/s40242-024-4060-2

• Reviews • Previous Articles     Next Articles

Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

QI Yi1, FAN Hailong2   

  1. 1. Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan;
    2. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo 001-0021, Japan
  • Received:2024-03-13 Online:2024-10-01 Published:2024-09-26
  • Contact: FAN Hailong,fanhl@icredd.hokudai.ac.jp E-mail:fanhl@icredd.hokudai.ac.jp
  • Supported by:
    This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (Nos.JP21K14676,JP24K17728) and the Project of the Institute for Chemical Reaction Design and Discovery (WPI-ICReDD) established by the World Premier International Research Initiative (WPI),MEXT,Japan.

Abstract: Vascular embolization treatment, a minimally invasive surgery for various blood vessel-related conditions, has emerged as a crucial method in treating such as hemorrhage, arteriovenous malformation, aneurysms, and hypervascular tumors. Liquid embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions, expanding the scope of embolization beyond the reach of solid agents. Recent strides in biomaterials and technologies have spurred the development of novel liquid embolic agents, addressing challenges posed by traditional options. This mini-review provides a concise overview of the recent progress in water-based liquid embolic agents, highlighting their potential to overcome limitations associated with current embolic materials. By presenting selected research outcomes, we illuminate advancements that enhance the efficacy of liquid embolic agents. Furthermore, the review outlines essential properties for effective liquid embolic agents, offering insights for future developments in this field.

Key words: Endovascular treatment, Liquid embolic agent, Hydrogel