Chemical Research in Chinese Universities ›› 2022, Vol. 38 ›› Issue (6): 1324-1343.doi: 10.1007/s40242-022-2256-x

• Reviews • Previous Articles     Next Articles

Recent Advances of Metal-Organic Frameworks-based Nanozymes for Bio-applications

WANG Yuda1, ZULPYA Mahmut1, ZHANG Xinyao1, XU Shihan3, SUN Jiao1, DONG Biao2   

  1. 1. Department of Cell Biology Norman Bethune College of Medicine, Jilin University, Changchun 130021, P. R. China;
    2. State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, P. R. China;
    3. Department of Bioengineering, University of Washington, Seattle, WA, United States
  • Received:2022-07-31 Online:2022-12-01 Published:2022-12-06
  • Contact: DONG Biao, SUN Jiao E-mail:dongb@jlu.edu.cn;jiaosun@jlu.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Nos.52050077, 82073475) and the Natural Science Foundation of Jilin Province, China(No.20210401059YY).

Abstract: Artificial nanoenzymes with enzyme-like catalytic activity have gradually become an alternative to natural enzymes due to their low production cost, high stability, and good tolerance. In recent years, various enzyme mimics have emerged with the rapid development of nano-teclnology. Metal-organic frameworks(MOFs) are a novel class of porous inorganic-organic hybrid materials made from metal ions/clusters and organic ligands, and MOFs-based nanozymes show great prospect in biosensing, biocatalysis, biomedical imaging, and therapeutic applications, due to unique properties, such as high specific surface area, high porosity, tunable morphology, and excellent biocatalytic properties. In this paper, the recent progresses concerning MOFs-based nanozymes are systematically summarized, including the synthesis, design strategies and related applications, which are divided into two major categories, namely, MOFs structured nanoenzymes and MOFs composite structured nanoenzymes. Meanwhile, the applications of various classifications of MOFs research are introduced. At the end, current challenges and future perspectives of MOFs-based nanozymes are also discussed. It is highly expected that this review on this important area can provide a meaningful guidance for tumor therapy, biosensing and other aspects.

Key words: Metal-organic framework, Biocatalytic, Nanoenzyme, Catalytic performance, Biosensing