Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (4): 846-854.doi: 10.1007/s40242-021-1197-0

• Reviews • Previous Articles     Next Articles

Dip-Pen Nanolithography(DPN): from Micro/Nano-patterns to Biosensing

LI Haonan1,2, WANG Zhao1,2, HUO Fengwei3, WANG Shutao1,2   

  1. 1. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China;
    2. University of Chinese Academy of Sciences, Beijing 100049, P. R. China;
    3. Key Laboratory of Flexible Electronics(KLOFE), Institute of Advanced Materials(IAM), Nanjing Tech University, Nanjing 211816, P. R. China
  • Received:2021-04-30 Revised:2021-06-06 Online:2021-08-01 Published:2021-07-27
  • Contact: WANG Shutao E-mail:stwang@mail.ipc.ac.cn

Abstract: Dip-pen nanolithography is an emerging and attractive surface modification technique that has the capacity to directly and controllably write micro/nano-array patterns on diverse substrates. The superior throughput, resolution, and registration enable DPN an outstanding candidate for biological detection from the molecular level to the cellular level. Herein, we overview the technological evolution of DPN in terms of its advanced derivatives and DPN-enabled versatile sensing patterns featuring multiple compositions and structures for biosensing. Benefitting from uniform, reproducible, and large-area array patterns, DPN-based biosensors have shown high sensitivity, excellent selectivity, and fast response in target analyte detection and specific cellular recognition. We anticipate that DPN-based technologies could offer great potential opportunities to fabricate multiplexed, programmable, and commercial array-based sensing biochips.

Key words: Dip-pen nanolithography, Micro/nano-array pattern, Biosensing