One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

doi:10.1007/s40242-019-8277-4

Chemical Research in Chinese Universities ›› 2019, Vol. 35 ›› Issue (2): 235-238.doi: 10.1007/s40242-019-8277-4

• Articles • Previous Articles Next Articles

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

JIANG Ling, YE Wenting, SU Weike

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China

Received:2018-09-03 Revised:2018-10-31 Online:2019-04-01 Published:2019-04-30
Contact: SU Weike E-mail:pharmlab@zjut.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21706236), the China Postdoctoral Science Foundation (No.2016M592012) and the Foundation for Selected Postdoctoral Project of Zhejiang Province, China(No.BSH1502150).

Abstract

Abstract: A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.

Key words: Porcine pancreatic lipase, Biocatalysis, One-pot synthesis, Higly functionalized 1,4-dihydropyridines

JIANG Ling, YE Wenting, SU Weike. One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase[J]. Chemical Research in Chinese Universities, 2019, 35(2): 235-238.

[1]	WANG Yilong, XU Yongkai, ZHANG Yun, SUN Aijun, HU Yunfeng. Utilization of One Novel Microbial Esterase WDEst9 in the Kinetic Resolution of (S)-Methyl 2-chloropropionate and (S)-Ethyl 2-chloropropionate [J]. Chemical Research in Chinese Universities, 2019, 35(5): 830-836.
[2]	HAN Qian, WANG Zumin, CHEN Xiaoyu, JIAO Chuangwei, LI Haiyan, YU Ranbo. Facile Synthesis of Fe-b ased MOFs(Fe-BTC) as Efficient Adsorbent for Water Purifications [J]. Chemical Research in Chinese Universities, 2019, 35(4): 564-569.
[3]	YANG Jianxin, YIN Yunxing, HE Zhenmin, ZHANG Zhiliu, LIN Xiaojuan, MA Rujian. Synthesis of 2-Hydroxymalononitrile [J]. Chemical Research in Chinese Universities, 2015, 31(5): 685-687.
[4]	YANG Jianxin, YIN Yunxing, HE Zhenmin, MA Li, LI Xin, ZHANG Zhiliu, LIN Xiaojuan, MA Rujian. 2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters [J]. Chemical Research in Chinese Universities, 2015, 31(3): 321-324.
[5]	AYCHILUHIM Tewodros Birhanu, VEDULA Rajeswar Rao. One Pot, Multi-component Synthesis of 3-[(4-Aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one [J]. Chemical Research in Chinese Universities, 2014, 30(4): 601-604.
[6]	CHEN Zhan-guo, XIA Wei, WEN Hua, WANG Dan, LI Ya-nan, HU Jun-li. Synthesis of 2-Oxazolines from Ethyl α-Cyanocinnamate Derivatives with Acetamide and N-Bromosuccinimide [J]. Chemical Research in Chinese Universities, 2013, 29(4): 699-705.
[7]	WANG Li-feng, CHEN Jie, SHAN Hui-jie, LI Wei. Synthesis of TP3 Fragment via One Pot Strategy and Its Immune Regulatory Activity [J]. Chemical Research in Chinese Universities, 2005, 21(5): 566-568.
[8]	Qi Deyao, Zhuang Yunlong, Chi Qijin. Biosensors Based on the Tissue of Plant as Catalytic Material for Amino Acids [J]. Chemical Research in Chinese Universities, 1990, 6(4): 295-299.

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Recommended Articles

Metrics

Comments