One Pot, Multi-component Synthesis of 3-[(4-Aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one

doi:10.1007/s40242-014-4036-8

Abstract

Abstract:

A series of 3-[(4-phenyl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one(4a―4g) and 3-{[4-(2-oxo- 2H-chromen-3-yl)-thiazol-2-yl]-hydrazono}-1,3-dihydro-indol-2-one(6a―6d) has been prepared in a one-step procedure from condensation reaction of isatin(1), thiosemicarbazide(2) and bromoacetophenones(3)/or 3-(2-bromoacetyl)coumarins(4). The method provides a simple and efficient route to prepare the compounds in good yields and in a short experimental time as compared to its stepwise procedure.

Key words: Isatin, Thiazole, Coumarin, Multi-component reaction, One-pot synthesis

AYCHILUHIM Tewodros Birhanu, VEDULA Rajeswar Rao. One Pot, Multi-component Synthesis of 3-[(4-Aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one[J]. Chemical Research in Chinese Universities, 2014, 30(4): 601-604.

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