Chemical Research in Chinese Universities ›› 2015, Vol. 31 ›› Issue (3): 321-324.doi: 10.1007/s40242-015-4495-6

• Letter • Previous Articles     Next Articles

2-Hydroxymalonitrile-A Useful Reagent for One-step Synthesis of α-Hydroxy Esters

YANG Jianxin1,2, YIN Yunxing2, HE Zhenmin2, MA Li2, LI Xin2, ZHANG Zhiliu2, LIN Xiaojuan2, MA Rujian2   

  1. 1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China;
    2. WuXi PharmaTech Co. Ltd., Shanghai 200131, P. R. China
  • Received:2014-12-18 Revised:2015-01-16 Online:2015-06-01 Published:2015-04-13
  • Contact: MA Rujian E-mail:marj@wuxiapptec.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.51209024).

Abstract:

An efficient one-pot synthesis of α-hydroxy esters by employing the useful reagent 2-hydroxymalononitrile reacting with an aldehyde or ketone in just one step has been reported.

Key words: α-Hydroxy ester, One-pot synthesis, 2-Hydroxymalononitrile