Copper-catalyzed ortho-Monofluorination of Aniline Derivatives with Selectfluor Directed by Picolinic Acid Amides

doi:10.1007/s40242-018-8113-2

Abstract

Abstract: A novel and facile method for selective ortho-C-H monofluorination of aniline derivatives was achieved using Selectfluor/Cu(OAc)₂/HOAc system. The reaction proceeded via electrophilic process with diverse substrates in acceptable moderate to high yields. The position selectivity was controlled by bidentate coordination of picolinic acid amides with copper.

Key words: Monofluorination, Aniline, Selectfluor, Picolinic acid, Copper

ZHANG Yingchao, WEN Chunxia, ZHANG Changjing, LI Jizhen. Copper-catalyzed ortho-Monofluorination of Aniline Derivatives with Selectfluor Directed by Picolinic Acid Amides[J]. Chemical Research in Chinese Universities, 2018, 34(4): 552-558.

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