Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release

doi:10.1007/s40242-017-6406-5

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (2): 294-297.doi: 10.1007/s40242-017-6406-5

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Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release

CAI Linjun¹, LI Junbo², WANG Shipeng², ZHAO Mengzhe², ZHAO Bing², JIANG Chunlai¹, KONG Wei¹

1. National Engineering Laboratory for AIDS Vaccine, College of Life Sciences, Jilin University, Changchun 130012, P. R. China;
2. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China

Received:2016-10-08 Revised:2016-12-10 Online:2017-04-01 Published:2017-01-09
Contact: JIANG Chunlai,E-mail:jiangcl@jlu.edu.cn E-mail:jiangcl@jlu.edu.cn
Supported by:
Supported by the National Natural Science Foundationof China(No.81401717), the Scientific Research Foundation for Returned Overseas Scholars, Ministry of Education of China and the Development Program of the Science and Technology of Jilin Province, China(No.20130206011YY).

Abstract

Abstract:

Magnetic titanium dioxide core-shell nanoparticles(Fe₃O₄@TiO₂ NPs) were synthesized as particles with appropriate size for intravenous injection. They subsequently were functionalized with p-aminothiophenol(PATP) to facilitate the covalent attachment of target drugs through azo coupling reaction, which can be universally observed in a variety of drugs containing phenols, anilines, and imidazoles. The proposed drug nanocarrier was designed to possess the ability to release drugs upon UV irradiation because of the photocatalytic property of the TiO₂ shells. All the results indicate the potential application of the Fe₃O₄@TiO₂ NPs in targeted drug delivery with greater chemical stability and universality.

Key words: Magnetic titanium dioxide, Targeted drug delivery, Azo coupling

CAI Linjun, LI Junbo, WANG Shipeng, ZHAO Mengzhe, ZHAO Bing, JIANG Chunlai, KONG Wei. Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release[J]. Chemical Research in Chinese Universities, 2017, 33(2): 294-297.

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Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release

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