Volume-related Efficiency of Gadolinium Polyoxometalates as MRI Contrast Agents

doi:10.1007/s40242-013-3061-3

Abstract

Abstract:

Two gadolinium polyoxometalates, KCs₄[Gd(α-SiW₁₁O₃₉)]·25H₂O(POM-1) and K₁₃[Gd(β₂-SiW₁₁O₃₉)₂]· 27H₂O(POM-2), have been evaluated as the candidates of potential magnetic resonance imaging T₁(longitudinal relaxation) contrast agents. Longitudinal relaxivities of POM-2 are much higher than those of POM-1 in pure water and protein solution, respectively. However, compared with POM-1, POM-2 interacts with protein more strongly through electrostatic interaction, which is comfirmed by the fluoresence quenching of human serum albumin(HSA) in solutions with different polyoxometalate concentrations. Meanwhile, POM-1 presentes much lower cytotoxicity in the cell viability tests.

Key words: Magnetic resonance imaging(MRI), Contrast agent, Polyoxometalate

KONG Da-liang, WEI Bo, ZHOU Sheng-yan, YANG Hai-shan, JIANG Yang. Volume-related Efficiency of Gadolinium Polyoxometalates as MRI Contrast Agents[J]. Chemical Research in Chinese Universities, 2013, 29(6): 1055-1058.

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