Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy

doi:10.1007/s40242-023-3122-1

Chemical Research in Chinese Universities ›› 2023, Vol. 39 ›› Issue (6): 884-890.doi: 10.1007/s40242-023-3122-1

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Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy

AQIB Raja Muhammad^1,2, YANG Changping^1,3, WU Xiaohui^1,2, WANG Yuang¹, FAN Jing^1,3, SHANG Yingxu¹, LIU Jianbing^1,2, and DING Baoquan^1,2,3

1. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for NanoScience and Technology, Beijing 100190, P.R. China;
2. University of Chinese Academy of Sciences, Beijing 100049, P.R. China;
3. School of Materials Science and Engineering, Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, P.R. China

Received:2023-05-13 Online:2023-12-01 Published:2023-11-18
Contact: LIU Jianbing, DING Baoquan E-mail:liujb@nanoctr.cn;dingbq@nanoctr.cn
Supported by:
This work was supported by the National Key R&D Program of China (Nos.2021YFA1200302, 2018YFA0208900), the National Natural Science Foundation of China (Nos.22025201, 22077023, 21721002), the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDB36000000), the CAS Project for Young Scientists in Basic Research (No.YSBR-036), the CAS Interdisciplinary Innovation Team, Youth Innovation Promotion Association CAS, and K. C. Wong Education Foundation (No.GJTD-2018-03).

Abstract

Abstract: Photothermal therapy is a direct and non-invasive therapeutic strategy. Herein, we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal therapy. In our design, two G4/hemin-based DNAzymes are precisely organized in a DNA template to mimic the function of horseradish peroxidase (HRP) for the catalytic oxidation of aniline. After polymerization, the polyaniline-coated DNA nanoparticles (PANI/DNA NPs) can be efficiently obtained as the photothermal agent to elicit a pronounced photothermal effect. After cellular uptake, the noticeable photothermal effect from 808 nm laser irradiation can achieve an efficient proliferation inhibition of tumor cells. This rationally developed photothermal agent based on DNA template-assisted polymerization presents a new avenue for the development of photothermal therapy.

Key words: Nucleic acid nanostructure, Self-assembly, Polymeriza-tion, Polyaniline, Photothermal therapy

AQIB Raja Muhammad, YANG Changping, WU Xiaohui, WANG Yuang, FAN Jing, SHANG Yingxu, LIU Jianbing, and DING Baoquan. Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy[J]. Chemical Research in Chinese Universities, 2023, 39(6): 884-890.

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Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy

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