Functional Peptides from One-bead One-compound High-throughput Screening Technique

doi:10.1007/s40242-023-2356-2

Abstract

Abstract: Combinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.

Key words: Combinatorial chemistry, One-bead one-compound (OBOC), Cyclic peptide, Peptide screening, Self-assembly

YAN Yaqiong, WANG Lei, WANG Hao. Functional Peptides from One-bead One-compound High-throughput Screening Technique[J]. Chemical Research in Chinese Universities, 2023, 39(1): 83-91.

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