A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

doi:10.1007/s40242-021-1168-5

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (4): 906-913.doi: 10.1007/s40242-021-1168-5

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A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

REN Yiqing¹, LIU Xinlong¹, GE Huan¹, GUO Yuanyuan¹, ZHANG Qiushuang¹, XIE Miao¹, WANG Ping², ZHU Xinyuan¹, ZHANG Chuan¹

1. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
2. Weigao Research Center, Shanghai 201203, P. R. China

Received:2021-04-13 Revised:2021-05-07 Online:2021-08-01 Published:2021-05-08
Contact: ZHANG Chuan E-mail:chuanzhang@sjtu.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China(Nos.2018YFC1106102, 2018YFA0902600), the National Natural Science Foundation of China(Nos.51973112, 51690151, 81871329), the Science Foundation of the Shanghai Municipal Science and Technology Commission, China(Nos.18JC1410800, 19JC1410300), and the Project of the Shanghai Outstanding Technology Leader, China(No.19XD1431900).

Abstract

Abstract: Acombinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA) delivery. In this approach, siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid self-assembly. Compared to small rigid siRNA duplex, the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester), resulting in the formation of a novel platform for efficient siRNA delivery.

Key words: Nucleic acid nanogel, Electrostatic compression, siRNA delivery, Self-assembly

REN Yiqing, LIU Xinlong, GE Huan, GUO Yuanyuan, ZHANG Qiushuang, XIE Miao, WANG Ping, ZHU Xinyuan, ZHANG Chuan. A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery[J]. Chemical Research in Chinese Universities, 2021, 37(4): 906-913.

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A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

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