Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (3): 424-429.

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Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

ZHAO Xu¹, LU Jun-rui¹, XIN Chun-wei¹, LU Bo-wei², BAO Xiu-rong¹, LI Jian-fa¹, LIU Ya¹, YANG Xu-yun¹, YUAN Yi¹

1. College of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China;
2. College of Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2011-11-24 Revised:2011-12-12 Online:2012-05-25 Published:2012-05-03
Contact: LU Jun-rui E-mail:lujunrui@tjut.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.20976135, 21176194).

Abstract

Abstract: According to the superposition principle of reinforcement of biological activities, 24 novel 1,4- disubstituted phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazoles was synthesized and characterized by 1H NMR, ¹³C NMR, elemental analysis and IR. All the target compounds were screened for their antibacterial potential in vitro against Monilia albican, Escherichia coli and Staphylococcus aureus. It was shown that all the compounds possessed efficient antibacterial activities at a concentration of 0.1 mg/mL, even at a concentration of 0.01 mg/mL, some of the compounds still exhibited antibacterial activities against Escherichia coli and Monilia albican. At last, the structure- activity relationship was discussed based on the antibacterial results.

Key words: 1,4-Disubstituted phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole, Antibacterial activity, Structureactivity relationship

ZHAO Xu, LU Jun-rui, XIN Chun-wei, LU Bo-wei, BAO Xiu-rong, LI Jian-fa, LIU Ya, YANG Xu-yun, YUAN Yi. Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole[J]. Chemical Research in Chinese Universities, 2012, 28(3): 424-429.

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Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

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