Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (5): 808-812.

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Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

CUI Lin-lin¹, MI Hao-yu¹, ZHANG Qun-li¹, WANG Wei-wei², YANG Li-juan², LIANG Yong-tao^1* and WANG En-si^1,2*

1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. College of Pharmacy, Jilin University, Changchun 130021, P. R. China

Received:2010-07-13 Revised:2010-11-17 Online:2011-09-25 Published:2011-09-06
Contact: WANG En-si;LIANG Yong-tao E-mail:wangss@jlu.edu.cn; liangyongtao2005@126.com

Abstract

Abstract: A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.

Key words: Immunosuppressant, Amino alcohol derivative, Bioactivity, Buchere-Bergs reaction

CUI Lin-lin, MI Hao-yu, ZHANG Qun-li, WANG Wei-wei, YANG Li-juan, LIANG Yong-tao* and WANG En-si*. Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)[J]. Chemical Research in Chinese Universities, 2011, 27(5): 808-812.

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Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

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