Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

doi:10.1007/s40242-016-6164-9

Abstract

Abstract:

A series of amino alcohol derivatives containing 1,3,4-oxadiazole moieties was synthesized with 7-bromo-2-tetralone as starting materials, 2,2-dimethyl-1,3-oxazolidine as intermediates and Strecker reaction and cyclization with POCl₃ as key steps. The structures of the key intermediate and target compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS. Some compounds have resulted in the generation of highly potent sphingosine 1-phosphate receptor type 1(S1P₁) agonists.

Key words: Amino alcohol, 1,3,4-Oxadiazole, Bioactivity, Strecker reaction

WU Yi, ZHAO Yanping, GUO Jing, LÜ Haoze, ZHENG Nan, WANG Ensi. Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole[J]. Chemical Research in Chinese Universities, 2016, 32(5): 760-767.

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