Synthesis and Immunosuppressive Activity of Amino Alcohol Containing Coumarin and Benzothiophene

doi:10.1007/s40242-016-6112-8

Abstract

Abstract:

A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chroma- none and 4,5-dihydrobenzo[b]-thiophen-5(4H)-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. Their characterization as sphingosine 1-phosphate(S1P) receptor agonists was reported.

Key words: Immunosuppressant, Amino alcohol derivative, Bioactivity, Suzuki reaction

WU Yi, SHANG Guanglei, TANG Qi, ZHANG Baozhen, WANG Ensi. Synthesis and Immunosuppressive Activity of Amino Alcohol Containing Coumarin and Benzothiophene[J]. Chemical Research in Chinese Universities, 2016, 32(3): 357-365.

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