Antioxidative Capacity of Irbesartan

Abstract

Abstract: The author investigated the antioxidant effect of irbesartan[2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)·phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one], an angiotensin receptor blocker(ARB), on the oxidation of erythrocytes induced by 2,2-[azobis(2-amidinopropane) hydrochloride](AAPH) and H2O2. The value of half concentration(IC50) of irbesartan to scavenge radicals was measured by reacting it with 2,2-[azinobis(3-ethylbenzothia- zoline-6-sulfonate) radical cation](ABTS+·). Activities of the catalase(CAT), superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and the content of malondialdehyde(MDA) in liver tissue and blood serum of normal-rats were measured by means of spectrophotometry to study the antioxidation function of irbesartan. Results of experiments show that irbesartan can scavenge ABTS+· and superoxide radicals effectively as well as inhibit AAPH-, H2O2-induced hemolysis of erythrocytes. Irbesartan can also increase the activities of GSH-Px, SOD, CAT and decrease the content of MDA of normal rats. So irbesartan is a good antioxidant.

Key words: Irbesartan, Antioxidant, Oxidative stress, Radical

WANG Mei-xue, ZHAO Xue-zhong*, GAI Chun-yu, LIU Hong-min, XU Yan-ping and LI . Antioxidative Capacity of Irbesartan[J]. Chemical Research in Chinese Universities, 2011, 27(1): 75-79.

References

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