Synthesis, Dimeric Crystal Structure, and Biological Activities of N-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N'-(2-trifluoromethyl-phenyl)-guanidine

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (6): 768-771.doi:

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Synthesis, Dimeric Crystal Structure, and Biological Activities of N-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N’-(2-trifluoromethyl-phenyl)-guanidine

HE Feng-qi, WANG Bao-lei and LI Zheng-ming

Elemento-Organic Chemistry Institute, State-Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2005-10-17 Revised:1900-01-01 Online:2006-11-25 Published:2006-11-25
Contact: LI Zheng-ming E-mail:nkzml@nk.sina.net

Abstract

Abstract: The title compound, N-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N’-(2-trifluoromethyl-phenyl)-guanidine, was synthesized and its structure was confirmed by using IR, MS, ¹H NMR, and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has a weak herbicidal activity.

Key words: Ketol-acid reductoisomerase, Synthesis, X-ray diffraction, Crystal structure, Biological activity

HE Feng-qi, WANG Bao-lei , LI Zheng-ming.

Synthesis, Dimeric Crystal Structure, and Biological Activities of N-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N’-(2-trifluoromethyl-phenyl)-guanidine

[J]. Chemical Research in Chinese Universities, 2006, 22(6): 768-771.

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Synthesis, Dimeric Crystal Structure, and Biological Activities of N-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N’-(2-trifluoromethyl-phenyl)-guanidine

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