Synthesis, Crystal Structure, and Biological Activities of 2-Oxo-2-aryl-1-(1,2,4-triazol-1-yl)ethyl phenylcarbamodithioate

Abstract

Abstract: The two title compounds, 2-oxo-2-p-tolyl-1-(1,2,4-triazol-1-yl)ethyl phenylcarbamodithioate(compound 3a) and 2-oxo-2-p-biphenyl-1-(1,2,4-triazol-1-yl)ethyl phenylcarbamodithioate(compound 3b), were synthesized and -identified by IR, EA and ¹H NMR spectra. The crystal structure of compound 3b was determined by X-ray diffraction analysis. The compound crystallized in a monoclinic system of space group P2₁/c with M_r=398.47(C₂₃H₁₈N₄OS), a=0.8769(2) nm, b=1.1924(2) nm, c=2.0440(6) nm, β=109.66(3)°, V=2.0126(8) nm³, Z=4,D_c=1.315 g/cm³, F(000)=832, μ=0.183 mm^-1, final R₁=0.0819. The biological test result shows that the two title compounds exhibit certain fungicidal activities.

Key words: 1,2,4-Triazole, Crystal structure, Biological activity, 1,2,4-Triazole, Crystal structure, Biological activity

XU Liang-zhong, ZHOU Kai, HU Zhi-qiang , BI Wen-zhao. Synthesis, Crystal Structure, and Biological Activities of 2-Oxo-2-aryl-1-(1,2,4-triazol-1-yl)ethyl phenylcarbamodithioate[J]. Chemical Research in Chinese Universities, 2006, 22(6): 765-767.

[1]	HUA Chen, YI Pin, LIU Wencong, WANG Mengfan, NIU Zheng, LANG Jianping. Coordination Polymers with Bipyridyl Diene and Triene Ligands: Synthesis, Structures and Luminescent Properties [J]. Chemical Research in Chinese Universities, 2022, 38(1): 209-216.
[2]	LIU Fei, LI Ren, YE Jing, REN Yujie, TANG Zhipeng, LI Rongchen, ZHANG Cuihua, LI Qunlin. Study of Aldo-keto Reductase 1C3 Inhibitor with Novel Framework for Treating Leukaemia Based on Virtual Screening and In vitro Biological Activity Testing [J]. Chemical Research in Chinese Universities, 2021, 37(3): 778-786.
[3]	ZHANG Wenqi, LIN Zhengguo, CHI Yingnan, HONG Jie, YAN Li, HU Changwen. Assembly of Three Scandium-containing Heteropolytungstates Based on a Building-block Synthetic Strategy [J]. Chemical Research in Chinese Universities, 2020, 36(6): 1161-1167.
[4]	ZANG Jiahe, ZHANG Qing'an, SUN Dalin. Crystal Structures and Electrochemical Properties of R_1.5Ca_1.5MgNi₁₄(R=Nd, Gd and Er) Hydrogen Storage Alloys [J]. Chemical Research in Chinese Universities, 2019, 35(6): 1040-1045.
[5]	WANG Dongmei, LOU Shengjun, YING Yiting, GUO Zhiqi, WANG Lijun. Assembly of Two Isostructural Metal-organic Frameworks Based on Hetero-N,O Donor Ligand for Detecting Nitro Explosives [J]. Chemical Research in Chinese Universities, 2019, 35(5): 762-766.
[6]	MA Xiao, WANG Xiaohong, SHANG Fan, DING Zimei, HANG Xiaojing, HUANG Jie. Studies on 3-Amino-4-(1H-tetrazol-5-yl)-furazan: Crystal Structure, Thermal Behavior and Energetic Performance [J]. Chemical Research in Chinese Universities, 2019, 35(5): 848-853.
[7]	ZHONG Liangxuan, LIU Mingyue, ZHANG Bowei, SUN Yaqiu, XU Yanyan. Syntheses, Crystal Structures, Magnetic and Near-infrared Luminescence Properties of 3d-4f Coordination Polymers Cu₂Pr₂, Cu₂Eu₂ and Cu₄Tb₂ [J]. Chemical Research in Chinese Universities, 2019, 35(4): 693-699.
[8]	YU Yanzhao, CAO Jiapeng, XU Yan. Two Pentavanadate-based Organic-inorganic Materials with Third-order NLO Properties [J]. Chemical Research in Chinese Universities, 2019, 35(1): 1-4.
[9]	DING Zimei, CAO Wenli, ZHENG Hui, HUANG Jie, XU Kangzhen, SONG Jirong. Synthesis, Structure Characteristic and Thermal Behavior of Two New Metal-organic Azo-triazole Compounds: [Zn(phen)₃]·ZTO·6H₂O and[Cu(phen)₃]·ZTO·6H₂O [J]. Chemical Research in Chinese Universities, 2018, 34(6): 1009-1013.
[10]	CHEN Xiang, ZENG Tian, ZHANG Cong, GUO Zhaoqi, LI Shuailei, MAI Tao, GAO Rong, MA Haixia. Crystal Structures, Thermal Behavior Analysis and Thermal Safety of Two Energetic Salts of Hydrazinyl-1,2,4,5-tetrazine with 3,5-Dinitrosalicylic Acid [J]. Chemical Research in Chinese Universities, 2018, 34(6): 959-964.
[11]	HUA Xuewen, WEI Wei, ZHU Liangliang, ZHOU Yunyun. Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives [J]. Chemical Research in Chinese Universities, 2018, 34(5): 744-750.
[12]	LIU Chao, LIU Yijie, ZHANG Lili, JIANG Kun, ZHANG Li. Two Coordination Compounds Bearing Bis(2-dimethylaminoethyl) Ether: Syntheses, Crystal Structures and Catalytic Application to the Henry Reaction [J]. Chemical Research in Chinese Universities, 2018, 34(3): 358-362.
[13]	WANG Jingyang, ZHANG Meng, XU Xiaodong, FENG Jing, WANG Yanli, ZHANG Milin, HAN Wei, CHEN Yitung, TIAN Guoxin. Synthesis and Characterization of [Cu(N-MeIm)₄(BF₄)₂] in Ionic Liquid [J]. Chemical Research in Chinese Universities, 2018, 34(1): 8-12.
[14]	ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia. Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole [J]. Chemical Research in Chinese Universities, 2017, 33(6): 864-868.
[15]	CHENG Dandan, WEI Wei, LI Yuxin, HUA Xuewen, ZHOU Yunyun, LIU Jingbo, LI Yonghong, YU Shujing, XIONG Lixia, LI Zhengming. Design, Synthesis and Biological Activities of Novel 4,5-Disubstituted-3-S-(β-D-acetylglycosyl)-1,2,4-triazole Derivatives [J]. Chemical Research in Chinese Universities, 2017, 33(5): 758-764.

Synthesis, Crystal Structure, and Biological Activities of 2-Oxo-2-aryl-1-(1,2,4-triazol-1-yl)ethyl phenylcarbamodithioate

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments