CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (3): 324-327.

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Studies on Interactions of Antibiotics with Serum Albumin by Surface Plasmon Resonance Biosensor

SUN Ying1,2, LIU Shi-chun1, LIU Xia1, SONG Da-qian1,2, BI Shu-yun1, ZHANG Han-qi1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, P. R. China;

    2. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, P. R. China
  • Received:2005-06-27 Online:2006-06-24 Published:2011-08-06
  • Supported by:

    Supported by the Research Fund for the Doctoral Program of Chinese Universites(No. 2003183035), and Science and Technology Developing Foundation of Jilin Province(No. 20040561).

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Abstract: Characterizing how chemical compounds binding to serum albumin is essential in evaluating drug candidates and is the focus of this study. A surface plasmon resonance biosensor developed in this laboratory was used to determine the binding constants of antibiotics with serum albumin. The binding constants of five antibiotics(azithromycin, spectinomycin, gentamycin, metacycline and kanamycin) with serum albumins were obtained.

Key words: Serum albumin, Surface plasmon resonance, Antibiotic, Human serum albumin(HSA), Bovine serum albumin(BSA)