Structure and Biological Activities of 2-(1,3-Dithiolan-2-ylidene)-1-phenyl-2-(1,2,4-triazol-1-yl)ethanone

Abstract

Abstract: In order to find leading compounds with an excellent fungicidal activity, the title compound 2-(1,3-dithiolan-2-yl-idene)-1-phenyl-2-(1,2,4-triazol-1-yl)ethanone was synthesized according to the biological isosterism and its stru-cture was confirmed by means of IR, MS, ¹H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test shows that the synthesized compound exhibits some biological activities.

Key words: 1H-1,2,4-Triazole, 1,3-Dithiolan, Crystal structure, Biological activity

XU Liang-zhong, LI Wei-hua, YU Guan-ping, QIN Yong-qi, YANG Shuang-hua, HOU Bao-rong. Structure and Biological Activities of 2-(1,3-Dithiolan-2-ylidene)-1-phenyl-2-(1,2,4-triazol-1-yl)ethanone[J]. Chemical Research in Chinese Universities, 2005, 21(5): 528-530.

[1]	HUA Chen, YI Pin, LIU Wencong, WANG Mengfan, NIU Zheng, LANG Jianping. Coordination Polymers with Bipyridyl Diene and Triene Ligands: Synthesis, Structures and Luminescent Properties [J]. Chemical Research in Chinese Universities, 2022, 38(1): 209-216.
[2]	LIU Fei, LI Ren, YE Jing, REN Yujie, TANG Zhipeng, LI Rongchen, ZHANG Cuihua, LI Qunlin. Study of Aldo-keto Reductase 1C3 Inhibitor with Novel Framework for Treating Leukaemia Based on Virtual Screening and In vitro Biological Activity Testing [J]. Chemical Research in Chinese Universities, 2021, 37(3): 778-786.
[3]	ZHANG Wenqi, LIN Zhengguo, CHI Yingnan, HONG Jie, YAN Li, HU Changwen. Assembly of Three Scandium-containing Heteropolytungstates Based on a Building-block Synthetic Strategy [J]. Chemical Research in Chinese Universities, 2020, 36(6): 1161-1167.
[4]	ZANG Jiahe, ZHANG Qing'an, SUN Dalin. Crystal Structures and Electrochemical Properties of R_1.5Ca_1.5MgNi₁₄(R=Nd, Gd and Er) Hydrogen Storage Alloys [J]. Chemical Research in Chinese Universities, 2019, 35(6): 1040-1045.
[5]	WANG Dongmei, LOU Shengjun, YING Yiting, GUO Zhiqi, WANG Lijun. Assembly of Two Isostructural Metal-organic Frameworks Based on Hetero-N,O Donor Ligand for Detecting Nitro Explosives [J]. Chemical Research in Chinese Universities, 2019, 35(5): 762-766.
[6]	MA Xiao, WANG Xiaohong, SHANG Fan, DING Zimei, HANG Xiaojing, HUANG Jie. Studies on 3-Amino-4-(1H-tetrazol-5-yl)-furazan: Crystal Structure, Thermal Behavior and Energetic Performance [J]. Chemical Research in Chinese Universities, 2019, 35(5): 848-853.
[7]	ZHONG Liangxuan, LIU Mingyue, ZHANG Bowei, SUN Yaqiu, XU Yanyan. Syntheses, Crystal Structures, Magnetic and Near-infrared Luminescence Properties of 3d-4f Coordination Polymers Cu₂Pr₂, Cu₂Eu₂ and Cu₄Tb₂ [J]. Chemical Research in Chinese Universities, 2019, 35(4): 693-699.
[8]	YU Yanzhao, CAO Jiapeng, XU Yan. Two Pentavanadate-based Organic-inorganic Materials with Third-order NLO Properties [J]. Chemical Research in Chinese Universities, 2019, 35(1): 1-4.
[9]	DING Zimei, CAO Wenli, ZHENG Hui, HUANG Jie, XU Kangzhen, SONG Jirong. Synthesis, Structure Characteristic and Thermal Behavior of Two New Metal-organic Azo-triazole Compounds: [Zn(phen)₃]·ZTO·6H₂O and[Cu(phen)₃]·ZTO·6H₂O [J]. Chemical Research in Chinese Universities, 2018, 34(6): 1009-1013.
[10]	CHEN Xiang, ZENG Tian, ZHANG Cong, GUO Zhaoqi, LI Shuailei, MAI Tao, GAO Rong, MA Haixia. Crystal Structures, Thermal Behavior Analysis and Thermal Safety of Two Energetic Salts of Hydrazinyl-1,2,4,5-tetrazine with 3,5-Dinitrosalicylic Acid [J]. Chemical Research in Chinese Universities, 2018, 34(6): 959-964.
[11]	HUA Xuewen, WEI Wei, ZHU Liangliang, ZHOU Yunyun. Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives [J]. Chemical Research in Chinese Universities, 2018, 34(5): 744-750.
[12]	LIU Chao, LIU Yijie, ZHANG Lili, JIANG Kun, ZHANG Li. Two Coordination Compounds Bearing Bis(2-dimethylaminoethyl) Ether: Syntheses, Crystal Structures and Catalytic Application to the Henry Reaction [J]. Chemical Research in Chinese Universities, 2018, 34(3): 358-362.
[13]	WANG Jingyang, ZHANG Meng, XU Xiaodong, FENG Jing, WANG Yanli, ZHANG Milin, HAN Wei, CHEN Yitung, TIAN Guoxin. Synthesis and Characterization of [Cu(N-MeIm)₄(BF₄)₂] in Ionic Liquid [J]. Chemical Research in Chinese Universities, 2018, 34(1): 8-12.
[14]	ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia. Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole [J]. Chemical Research in Chinese Universities, 2017, 33(6): 864-868.
[15]	CHENG Dandan, WEI Wei, LI Yuxin, HUA Xuewen, ZHOU Yunyun, LIU Jingbo, LI Yonghong, YU Shujing, XIONG Lixia, LI Zhengming. Design, Synthesis and Biological Activities of Novel 4,5-Disubstituted-3-S-(β-D-acetylglycosyl)-1,2,4-triazole Derivatives [J]. Chemical Research in Chinese Universities, 2017, 33(5): 758-764.

Structure and Biological Activities of 2-(1,3-Dithiolan-2-ylidene)-1-phenyl-2-(1,2,4-triazol-1-yl)ethanone

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments