Mass Spectrometry of 2a,4-Disubstituted 5-Benzoyl-2a,3,4,5-tetrahydro-2-phenoxy-azeto[1,2-a][1,5]benzodiazepin-1(2H)-ones Under Electron Impact Ionization Conditions

Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (4): 452-456.

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Mass Spectrometry of 2a,4-Disubstituted 5-Benzoyl-2a,3,4,5-tetrahydro-2-phenoxy-azeto[1,2-a][1,5]benzodiazepin-1(2H)-ones Under Electron Impact Ionization Conditions

XU Jia-xi, HUANG Xu

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education of China, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China

Received:2004-09-20 Online:2005-07-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(Nos.20272002 and 20472005), the Excellent Young Teachers Program, the Scientific Research Foundation for the Returned Oversea Chinese Scholars of Ministry of Education of China, and the President Grant of Peking University.

Abstract

Abstract: The mass spectrometric fragmentation of 2a,4-disubstituted 5-benzoyl-2a,3,4,5-tetrahydro-2-phenoxy-azeto[1,2-a][1,5]benzodiazepin-1(2H)-ones has been investigated by means of mass-analyzed ion kinetic energy spectrometry under electron impact ionization conditions. All compounds tend to lose different moieties, such as phenoxy, phenoxy and H, and phenoxyketene. Both [M⁺-PhO] and [M⁺-PhOH] ions could further lose CO, and the [M⁺-PhOCH＝C＝O] ions could lose propene or styrene, PhCON, PhCOHN, and other fragments.

Key words: Azeto[1,2-a][1,5]benzodiazepin-1(2H)-one, Mass spectrometry, Fragmentation, Mechanism

XU Jia-xi, HUANG Xu. Mass Spectrometry of 2a,4-Disubstituted 5-Benzoyl-2a,3,4,5-tetrahydro-2-phenoxy-azeto[1,2-a][1,5]benzodiazepin-1(2H)-ones Under Electron Impact Ionization Conditions[J]. Chemical Research in Chinese Universities, 2005, 21(4): 452-456.

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Mass Spectrometry of 2a,4-Disubstituted 5-Benzoyl-2a,3,4,5-tetrahydro-2-phenoxy-azeto[1,2-a][1,5]benzodiazepin-1(2H)-ones Under Electron Impact Ionization Conditions

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