Synthesis, Structure Characterization and Biological Activity of Adenine Salt of 12-Phosphotungstic Acid

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (3): 258-261.

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Synthesis, Structure Characterization and Biological Activity of Adenine Salt of 12-Phosphotungstic Acid

LI Juan^1,2, QI Yan-fei¹, HAN Zheng-bo¹, WANG En-bo¹, LI Jing², WU Xin-yu², WANG Hong-fang²

1. Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China;
2. College of Public Health, Jilin University, Changchun 130021, P. R. China

Received:2003-12-31 Online:2004-06-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(No.20171010).

Abstract

Abstract: A novel adenine(Ade) salt of 12-phosphotungstic acid was synthesized and characterized by elemental analyses, IR, ¹H NMR, CV and single crystal X-ray diffraction. The compound crystallized in a triclinic system with a space group P1 and a=1.3108(3) nm, b=1.3515(3) nm, c=1.3870(3) nm, V=2.0217(7) nm³, Z=1, R₁=0.0391, wR₂=0.0959. The structure unit of the complex was constructed from [HPW₁₂·O₄₀]^-, (C₅H₆N₅)⁺ and C₃H₇NO, which further extends to form a novel three-dimensional host-guest network via hydrogen-bonding interactions. The anti-tumor activity of the compound was examined in two human tumor cell lines in vitro.

Key words: Polyoxometalate, 12-Phosphotungstic acid, Adenine, Crystal structure, Anti-tumor activity

LI Juan, QI Yan-fei, HAN Zheng-bo, WANG En-bo, LI Jing, WU Xin-yu, WANG Hong-fang. Synthesis, Structure Characterization and Biological Activity of Adenine Salt of 12-Phosphotungstic Acid[J]. Chemical Research in Chinese Universities, 2004, 20(3): 258-261.

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Synthesis, Structure Characterization and Biological Activity of Adenine Salt of 12-Phosphotungstic Acid

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