Spectroelectrochemical Studies on the Interactions of Complexes of Cu(phen)22+ and Cu(bpy)22+ with DNA

Chemical Research in Chinese Universities ›› 1997, Vol. 13 ›› Issue (2): 117-125.

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Spectroelectrochemical Studies on the Interactions of Complexes of Cu(phen)₂²⁺ and Cu(bpy)₂²⁺ with DNA

ZHAO Guang-chao, ZHU Jun-jie, CHEN Hong-yuan

Department of Chemistry, the State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093

Received:1997-02-10 Online:1997-04-24 Published:2011-08-17
Supported by:
Supported by the National Natur al Science Foundation of China.

Abstract

Abstract: The interactions of the complexes of Cu(phen)₂²⁺ and Cu(bpy)₂²⁺ with DNA were investigated with electrochemistry and spectroelectrochemistry. Binding constants( K_n+ ) and the reaction model were obtained from their electrochemical behavior and electrochemical data. The binding constants( K₂₊ ) for Cu(phen)₂²⁺-DNA and Cu(bpy)₂²⁺-DNA were 8.51×10³ L·mol^-1 and 3.27×10³ L·mol^-1, and K₊'s were 3.09×10⁴ L·mol^-1 and 5.66×10³ L·mol^-11 respectively. The spectroscopic characteristics of the complexes of Cu(phen)₂²⁺-DNA and Cu(bpy)₂²⁺-DNA were studied in detail. Some significant spectroelectrochemical data were obtained. The interaction of DNA with complexes was described.

Key words: DNA, Interaction, Cu(phen)₂²⁺, Cu(bpy)₂²⁺, Spectroelectrochemistry

ZHAO Guang-chao, ZHU Jun-jie, CHEN Hong-yuan . Spectroelectrochemical Studies on the Interactions of Complexes of Cu(phen)₂²⁺ and Cu(bpy)₂²⁺ with DNA[J]. Chemical Research in Chinese Universities, 1997, 13(2): 117-125.

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Spectroelectrochemical Studies on the Interactions of Complexes of Cu(phen)₂²⁺ and Cu(bpy)₂²⁺ with DNA

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