Ultrasensitive Detection of Hepatitis C Virus DNA Subtypes Based on Cucurbituril and Graphene Oxide Nano-composite

doi:10.1007/s40242-020-9111-8

Chemical Research in Chinese Universities ›› 2020, Vol. 36 ›› Issue (2): 307-312.doi: 10.1007/s40242-020-9111-8

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Ultrasensitive Detection of Hepatitis C Virus DNA Subtypes Based on Cucurbituril and Graphene Oxide Nano-composite

JIANG Ping^1,2, LI Yifei², JU Ting^1,2, CHENG Wenbo^3,4, XU Jianhua⁵, HAN Kun^1,2,3

1. University of Science and Technology of China, Hefei 230027, P. R. China;
2. CAS Key Lab of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China;
3. University of Chinese Academy of Sciences, Beijing 100049, P. R China;
4. Institute of Optics and Electronics, Chengdu 610209, P. R. China;
5. Laboratory of Oncology Science and Molecular Biology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan 528333, P. R. China

Received:2019-12-25 Revised:2020-02-14 Online:2020-04-01 Published:2020-02-13
Contact: HAN Kun E-mail:hank@sibet.ac.cn
Supported by:
Supported by the National Key R&D Program of China(No.2017YFC0108505]), the Youth Innovation Promotion Association of China(No.2015261), the National Natural Science Foundation of China(No.31500805), the "333 High-level Talents Training Project of Jiangsu Province", China and the Science and Technology Program of Suzhou, China(No.SYG201508).

Abstract

Abstract: Infectious of hepatitis C viruses(HCVs) lead to hepatic fibrosis, cirrhosis even hepatoma. Developing rapid and sensitive diagnostic method for HCV is of great importance. Based on the host-and-guest interaction between cucurbit[7]uril(CB[7]) and methylene blue(MB), a CB[7]-graphene nano-composite(CB[7]-N₃-GO) is raised for the electrochemical detection of HCV DNA. The method is able to linearly detect the HCV nucleic acid in the range of 0.2-10 nmol/L with detection limit as low as 160.4 pmol/L. The proposed detection strategy is able to discriminate the 1b and 6k subtypes of HCV and has a prospective potential in the blood screen for HCV in clinical diagnosis.

Key words: Hepatitis C virus, Cucurbit[7]uril, Graphene, Nano-composite, Assay

JIANG Ping, LI Yifei, JU Ting, CHENG Wenbo, XU Jianhua, HAN Kun. Ultrasensitive Detection of Hepatitis C Virus DNA Subtypes Based on Cucurbituril and Graphene Oxide Nano-composite[J]. Chemical Research in Chinese Universities, 2020, 36(2): 307-312.

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Ultrasensitive Detection of Hepatitis C Virus DNA Subtypes Based on Cucurbituril and Graphene Oxide Nano-composite

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