Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure

doi:10.1007/s40242-019-9162-x

Abstract

Abstract: Highly-ordered inorganic chiral mesoporous silica(HOCMS) has attracted substantial interest in recent decades. High performance liquid chromatography(HPLC) is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS. The column was fabricated by conventional high pressure slurry packing. Eighteen racemates, including alcohols, ketones, amines, aldehydes and organic acids, were resolved on the column. Good chiral separations of hydrobenzoin, metoprolol, propranolol hydrochloride, 4-methyl-2-pentanol, omeprazole, 2,2'-furoin and ketoprofen were obtained. The relative standard deviations for five replicate separations of racemates were 0.1%-0.16% for retention time and 1.73%-2.64% for peak areas. The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC.

Key words: Highly-ordered inorganic chiral mesoporous silica, Chiral stationary phase, High performance liquid chromatography, Enantioseparation

PENG Bo, FU Shiguo, LI Yanxia, ZHANG Junhui, XIE Shengming, LI Li, LYU Yun, DUAN Aihong, CHEN Xuexian, YUAN Liming. Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure[J]. Chemical Research in Chinese Universities, 2019, 35(6): 978-982.

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