Quantitative Analysis and Chemical Fingerprint Similarity for Quality Control of the Seeds of Paeonia suffruticosa Andr. by HPLC

doi:10.1007/s40242-017-6463-9

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (4): 546-551.doi: 10.1007/s40242-017-6463-9

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Quantitative Analysis and Chemical Fingerprint Similarity for Quality Control of the Seeds of Paeonia suffruticosa Andr. by HPLC

TIAN Xiao¹, YANG Meiqi¹, GUO Sen¹, LIU Qingchao¹, ZHANG Li¹, HO Chi-Tang², BAI Naisheng¹

1. Department of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi'an 710069, P. R. China;
2. Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA

Received:2016-11-23 Revised:2017-03-15 Online:2017-08-01 Published:2017-05-08
Contact: BAI Naisheng E-mail:nsbai@nwu.edu.cn
Supported by:
Supported by the Forestry Science and Technology Program of Shaanxi Province，China（No.2014-KJ01）.

Abstract

Abstract:

According to the General Office of the State Council of China, tree peony seeds(TPSs, Paeonia suffruticosa Andr.) are considered an emerging source for edible oil. In Chinese folk medicine, TPSs are used for alleviating waist and leg pain. In the present study, a simple, accurate and rapid fingerprint method based on high performance liquid chromatography with diode array detection(HPLC-DAD) was developed and validated to quantify the profiles of ten representative compounds in TPSs. All standard calibration curves exhibited good linearity(R²>0.9995) in the HPLC-DAD analysis. The recovery of the standards ranged from 96.37% to 102.10%. The results show that stilbenoids are the major constituents in TPSs, and their total content ranges from 25.71 mg/g to 54.03 mg/g. Suffruticosol A, suffruticosol B, trans-ε-viniferin, ampelopsin E and paeoniflorin are the major components in methanolwater(80:20, volume ratio) extracts with average contents of 3.962, 12.264, 5.826, 14.060 and 12.755 mg/g, respectively. Additionally, 14 batches of seeds collected from different regions were used to establish a reference fingerprint. Their similarity values were higher than 0.944 except for the sample(0.863) from Linxia. These results collectively indicate that the quantitative HPLC fingerprint method can serve as a prerequisite quality control for TPSs, and is a promising resource for developing new herbal or food products.

Key words: Paeonia suffruticosa Andr., Fingerprint, High performance liquid chromatography with diode array detection(HPLC-DAD), Quality analysis, Similarity

TIAN Xiao, YANG Meiqi, GUO Sen, LIU Qingchao, ZHANG Li, HO Chi-Tang, BAI Naisheng. Quantitative Analysis and Chemical Fingerprint Similarity for Quality Control of the Seeds of Paeonia suffruticosa Andr. by HPLC[J]. Chemical Research in Chinese Universities, 2017, 33(4): 546-551.

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Quantitative Analysis and Chemical Fingerprint Similarity for Quality Control of the Seeds of Paeonia suffruticosa Andr. by HPLC

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