Eco-friendly and Cleaner Process Using Online Microwave-assisted Steam Extraction Coupled with Solid-phase Extraction for Trace Analysis of Sulfonamides in Animal Feed

doi:10.1007/s40242-018-8166-2

Abstract

Abstract: An environmentally friendly method for extracting sulfonamides(SAs) residues from animal feed was described and applied. The method used online microwave-assisted steam extraction coupled with solid phase extraction(MASE-SPE), which was followed by the analysis using high performance liquid chromatography-mass spectrometry(HPLC-MS/MS). The SAs residues were extracted successively with water steam under microwave irradiation, and thus directly introduced into an SPE column containing cation-exchange resin. The SAs were then eluted with methanol-ammonia(90:10, volume ratio) from the SPE column and followed by HPLC-MS/MS. The limits of detection(LODs) for the analytes ranged from 0.24 ng/g to 0.49 ng/g. The limits of quantification(LOQs) ranged from 0.82 ng/g to 1.63 ng/g. Average recoveries of SAs were 76.3%-92.1%. The developed method was a reliable and environmentally friendly alternative to previous methods with respect to time, solvent and labor consumption for the analysis of SAs in animal foodstuffs.

Key words: High performance liquid chromatography-mass spectrometry, Microwave-assisted steam extraction, Solid-phase extraction, Sulfonamide, Animal feed

LI Guijie, LIU Chang, WANG Dawei, DING Lan. Eco-friendly and Cleaner Process Using Online Microwave-assisted Steam Extraction Coupled with Solid-phase Extraction for Trace Analysis of Sulfonamides in Animal Feed[J]. Chemical Research in Chinese Universities, 2018, 34(6): 893-898.

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