CRCU

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (4): 647-652.doi: 10.1007/s40242-013-2516-x

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Ionic Liquid-based Microwave-assisted Liquid-liquid Microextraction and High Performance Liquid Chromatography Determination of Sulfonamides from Animal Oils

FENG Xu-dong1, LIANG Fang-hui2, SU Rui1, WU Li-jie1, LI Xue-yuan1, WANG Xing-hua1, ZHANG Han-qi1, YU Ai-min1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, P. R. China;
    2. Department of Pharmacy, Changchun Medical College, Changchun 130117, P. R. China
  • Received:2012-12-21 Revised:2013-03-12 Online:2013-08-01 Published:2013-07-15
  • Contact: YU Ai-min E-mail:yu_anal@163.com
  • Supported by:

    Supported by the Key Projects of Science and Technology Development Plan of Jilin Province, China(No.20125006) and the Scientific Forefront and Interdisciplinary Innovation Project of Jilin University, China(No.450060481018).

Cited

18

Abstract:

The authors performed ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME) coupled with high performance liquid chromatographic separation for the determination of 6 sulfonamides (SAs) from animal oils. The target analytes were extracted from animal oil samples with sodium hydroxide solution containing 1-butyl-3-methylimidazolium tetrafluoroborateand as the extraction solvent under microwave irradiation. The experimental parameters of the IL-based MALLME, including types of ILs, volume of IL, amount of ion-pairing agent(NH4PF6), pH value of sample solution, and extraction temperature and time were evaluated. The limits of detection and quantification obtained were in a range of 0.4―0.5 μg/kg and a range of 1.2―1.8 μg/kg, respectively. The accuracy of the method was evaluated by analyzing five spiked animal oil samples at two fortified levels(5 and 50 μg/kg), and the recoveries of SAs varied from 81.4% to 114.5% with relative standard deviations ranging from 0.8% to 9.0%.

Key words: Ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME), High performance liquid chromatography(HPLC), Sulfonamide, Animal oil