A New Biphenylcarbonitrile Based Fluorescent Sensor for Zn2+ Ions and Application in Living Cells

doi:10.1007/s40242-017-7084-z

Abstract

Abstract:

A new and efficient fluorescent sensor 4'-hydroxy-3'-[(4-antipyrineimino) methyl]-4-biphenylcarbonitrile (L) was prepared for the selective detection of Zn²⁺ in aqueous ethanol medium.When excited at 419 nm,the fluorescent intensity of sensor L at 507 nm was remarkably increased more than 54-fold after adding Zn²⁺ ions.The strong green emission of the solution can be easily identified by naked eye under UV light.Thus,sensor L behaves as a naked eye fluorescent-turn on‖ detector for Zn²⁺ ions.The fluorescence enhancement might be attributed to the inhibition of excited state intramolecular proton transfer (ESIPT) and C=N isomerization as well as the chelation enhanced fluorescence (CHEF) effect.The complex solution of sensor L with Zn²⁺ ions exhibited reversibility with ethylene diamine tetraacetic acid (EDTA) and the probe could be recycled for further use.Notably,sensor L could clearly distinguish Zn²⁺ from Cd²⁺.The interaction of sensor L with zinc ions was investigated by means of FTIR, 1H NMR and HRMS spectroscopy.Furthermore,sensor L has been applied for cell imaging studies.

Key words: Fluorescent chemosensor, Recognition, Zn²⁺, Cell imaging

FENG Jia, SHAO Xiuqing, SHANG Zhuobin, CHAO Jianbin, WANG Yu, JIN Weijun. A New Biphenylcarbonitrile Based Fluorescent Sensor for Zn²⁺ Ions and Application in Living Cells[J]. Chemical Research in Chinese Universities, 2017, 33(5): 695-701.

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A New Biphenylcarbonitrile Based Fluorescent Sensor for Zn²⁺ Ions and Application in Living Cells

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