Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (6): 990-993.

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Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives

LIU Zhen-ming¹, WU Lei², SUN Jing², YAN Chao-guo²

1. Analysis and Test Center, Yangzhou University, Yangzhou 225002, P. R. China;
2. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

Received:2012-02-07 Revised:2012-02-29 Online:2012-11-25 Published:2012-11-09
Contact: YAN Chao-guo E-mail:cgyan@yzu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21172189).

Abstract

Abstract:

A one-pot sequential reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]-quinoline derivatives has been developed. The reaction included firstly the Cu-catalyzed three-component reaction of isoquinoline(quinoline), acetylenedicarboxylate and alkynylbenzene and then Cs₂CO₃-promoted intramolecular cyclization reaction of initially formed 1-alkenyl-2-alkynyl-1,2-dihydroisoquinoline(1,2-dihydroquinoline).

Key words: Indolizine, Pyrrolo[2,1-a]isoquinoline, One-pot reaction, Three-component reaction

LIU Zhen-ming, WU Lei, SUN Jing, YAN Chao-guo. Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives[J]. Chemical Research in Chinese Universities, 2012, 28(6): 990-993.

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Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives

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