Zirconium-mediated Selective Synthesis of Quinoline Derivatives

doi:10.1007/s40242-016-6021-x

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (4): 621-624.doi: 10.1007/s40242-016-6021-x

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Zirconium-mediated Selective Synthesis of Quinoline Derivatives

MEN Yican¹, ZHANG Jiqian², ZHOU Lishan³, LI Junqiu¹, LIU Jun¹, LI Juan¹, QU Hongmei¹

1. Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin Key Laboratory of Biological and Pharmaceutical Engineering, Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China;
2. Nantong Dongchang Chemical Industrial Co., Ltd., Nantong 226407, P. R. China;
3. China National Offshore Oil Corp., Tianjin Chemical Research and Design Institute, Tianjin 300131, P. R. China

Received:2016-01-20 Revised:2016-03-18 Online:2016-08-01 Published:2016-05-30
Contact: QU Hongmei E-mail:ququhongmei@126.com
Supported by:
Supported by the National Natural Science Foundation of China(No.21102099).

Abstract

Abstract:

A series of quinoline derivatives was obtained in high yields by an efficient one-pot reaction of substituted o-diiodobenzenes with azazirconacyclopentadienes, which were conveniently prepared from one internal alkyne and one nitrile mediated by zirconocene. This proposed synthetic method provides a feasible way to the synthesis of large N-heterocyclic π-conjugated molecules.

Key words: Azazirconacyclopentadiene, One-pot reaction, Quinoline derivative, Zirconocene

MEN Yican, ZHANG Jiqian, ZHOU Lishan, LI Junqiu, LIU Jun, LI Juan, QU Hongmei. Zirconium-mediated Selective Synthesis of Quinoline Derivatives[J]. Chemical Research in Chinese Universities, 2016, 32(4): 621-624.

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Zirconium-mediated Selective Synthesis of Quinoline Derivatives

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