One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-a]pyridines Under Solvent-free Conditions

doi:10.1007/s40242-014-3520-5

Abstract

Abstract:

A direct and efficient approach to synthesize imidazo[1,2-a]pyridines through three-component one-pot reaction of 2-aminopyridine, aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed. This method provides a rapid access to substituted imidazo[1,2-a]pyridines with good yields(up to 85%).

Key words: Copper nanoparticle, Three-component reaction, Solvent-free condition, 2-Aminopyridine, Aldehyde, Alkyne

ZONG Chenglong, ZENG Runsheng, ZOU Jianping. One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-a]pyridines Under Solvent-free Conditions[J]. Chemical Research in Chinese Universities, 2014, 30(4): 632-638.

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