Aryl-guanidine/Pd-catalyzed Suzuki Cross-coupling Reaction at Room Temperature

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (2): 242-244 .

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Aryl-guanidine/Pd-catalyzed Suzuki Cross-coupling Reaction at Room Temperature

LI Yan-chun¹, LIN Ying-jie¹, ZHANG Suo-bo², LI Sheng-hai², DUAN Hai-feng¹

1. Departent of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2011-04-18 Revised:2011-07-22 Online:2012-03-25 Published:2012-03-08
Supported by:
Supported by the National Natural Science Foundation of China(Nos.20802071, 21074133).

Abstract

Abstract: Four aryl-guanidines(AG) were synthesized and used for the palladium-catalyzed Suzuki cross-coupling reaction to test the catalytic activity. In the presence of steric bulk AG, when aryl bromide and arylboronic acid were used as the reactants, the Suzuki reaction could be carried out smoothly at room temperature in aqueous solvent to afford the cross-coupling product in high yield. This catalysis system was also successful for the coupling of activated aryl chlorides at room temperature.

Key words: Aryl-guanidine, Suzuki reaction, Palladium, Ligand

LI Yan-chun, LIN Ying-jie, ZHANG Suo-bo, LI Sheng-hai, DUAN Hai-feng. Aryl-guanidine/Pd-catalyzed Suzuki Cross-coupling Reaction at Room Temperature[J]. Chemical Research in Chinese Universities, 2012, 28(2): 242-244 .

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Aryl-guanidine/Pd-catalyzed Suzuki Cross-coupling Reaction at Room Temperature

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