Chemical Research in Chinese Universities ›› 2018, Vol. 34 ›› Issue (6): 923-928.doi: 10.1007/s40242-018-8129-7

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Facile Synthesis of 1,5-Diaryl-4-pyridyl-1,2,3-triaozle Derivatives

WANG Yingnan, WEI Chiyu, SONG Zhiguang   

  1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China
  • Received:2018-04-18 Online:2018-12-01 Published:2018-08-23
  • Contact: SONG Zhiguang E-mail:szg@jlu.edu.cn
  • Supported by:
    Supported by the Development Project of the Pharmaceutical Industry of Jilin Province, China(Nos.20150311070YY, 20170307024YY).

Abstract: A feasible approach to synthesize 1,5-diaryl-4-pyridyl-1,2,3-triaozle via a sequential route from 2-alkynyl pyridine was developed. In this work, KOH was identified as a crucial base to promote the Pd-catalyzed arylation step. Compared to the reported methods, this protocol largely improved the reaction efficiency with overall excellent yield and good functional group tolerance.

Key words: 1,2,3-Triazole, Arylation, Triazole ligand