Resolution of 2-Octanol via Lipase-catalyzed Enantioselective Acetylation in Organic Solvents

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (5): 575-578.

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Resolution of 2-Octanol via Lipase-catalyzed Enantioselective Acetylation in Organic Solvents

WANG Zhi¹, LI Zheng-qiang¹, Yu Da-hai¹, WENG Liang¹, LIU Ming², ZHANG Gui-rong¹, CAO Shu-gui¹

1. Key Laboratory for Molecular Enzymology and Engineering of Educational Ministry, Jilin University, Changchun 130023, P. R. China;
2. Life Science and Technology Institute of Jilin University, Changchun 130023, P. R. China

Received:2003-06-24 Online:2004-10-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(No.20072011 and 20272017).

Abstract

Abstract: The lipases from different sources were screened for their ability to catalyze the resolution of 2-octanol in organic solvents with vinyl acetate as the acylating reagent.The medium effect has been studied on the irreversible transesterification with varying water activity(a_w).The influence of vinyl acetate concentration on it has also been investigated.Under the optimal conditions, the enantiomeric ratio(E value) of pseudomonas fluorescence lipase(PFL) exceeded 200 with an enantiomeric excess(e.e.) of S-2-octanol above 99% at a 51% degree of conversion.

Key words: Lipase, Resolution, Activity, Enantioselectivity, 2-Octanol

WANG Zhi, LI Zheng-qiang, Yu Da-hai, WENG Liang, LIU Ming, ZHANG Gui-rong, CAO Shu-gui. Resolution of 2-Octanol via Lipase-catalyzed Enantioselective Acetylation in Organic Solvents[J]. Chemical Research in Chinese Universities, 2004, 20(5): 575-578.

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Resolution of 2-Octanol via Lipase-catalyzed Enantioselective Acetylation in Organic Solvents

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