Determination of Heroin Based on Analyte Pulse Perturbation to an Oscillating Chemical Reaction

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (5): 534-538.

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Determination of Heroin Based on Analyte Pulse Perturbation to an Oscillating Chemical Reaction

REN Jie¹, GAO Jin-zhang¹, Suo-nan¹, ZHAO Guo-hu¹, YANG Wu¹, LÜ Dong-yu¹, SUN Kan-jun¹, LI Chong-yang²

1. Institute of Chemistry, Northwest Normal University, Lanzhou 730070, P. R. China;
2. Gansu Political Science and Law Institute, Lanzhou 730070, P. R. China

Received:2003-01-02 Online:2004-10-24 Published:2011-08-06
Supported by:
Supported by the Project of International Cooperation between China and Ukraine (No.043-05) and the Project of KJCXGC-01, Northwest Normal University, China.

Abstract

Abstract: A new analytical method is proposed for the determination of heroin based on a sequential perturbation caused by trace amounts of heroin in the Cu (Ⅱ)-catalyzed oscillating reaction between hydrogen peroxide and sodium thiocyanate in an alkaline medium with the aid of a continuous-flow stirred tank reactor (CSTR).The method relies on the linear relationship between the change in oscillation period of the system and the concentration of heroin, with a detecting limit of 4.0× 10^-7 mol/L.The calibration curve fits a linear equation very well when the concentration of heroin is in the range of 2.0 × 10^-6_ 1.2 × 10^-5 mol/L (r = 0.9971).This method features good precision(RSD= 0.98%).The influences of temperature, injection point, flow rate and reaction variables on the oscillation period were investigated in detail and a possible mechanism of the performance of heroin in the Cu( Ⅱ )-catalyzed oscillating reaction system is also discussed.The proposed method opens a new avenue for the determination of heroin.

Key words: Cu(Ⅱ)-catalyzed oscillating reaction, Heroin, Analyte pulse perturbation technique (APP), Mechanism, Continuous-flow stirred tank reactor(CSTR)

REN Jie, GAO Jin-zhang, Suo-nan, ZHAO Guo-hu, YANG Wu, LÜ Dong-yu, SUN Kan-jun, LI Chong-yang. Determination of Heroin Based on Analyte Pulse Perturbation to an Oscillating Chemical Reaction[J]. Chemical Research in Chinese Universities, 2004, 20(5): 534-538.

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Determination of Heroin Based on Analyte Pulse Perturbation to an Oscillating Chemical Reaction

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