Studies on Model Interaction of Keggin-type Polyoxometalates with Nucleic Acid

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (1): 6-9.

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Studies on Model Interaction of Keggin-type Polyoxometalates with Nucleic Acid

PENG Jun¹, LI Wen-zhuo¹, ZHAO Xian-ling², HAN Zhan-gang¹, HUANG Bai-qu²

1. Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China;
2. Institute of Genetic and Cytology, Northeast Normal University, Changchun 130024, P. R. China

Received:2002-12-25 Online:2004-02-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(No.20271011) and the Ministry of Education of China(No.2001345).

Abstract

Abstract: Keggin anions behave differently from each other when they react with nucleic acids. The molybdenum series exhibits oxidative cleavage activity towards AMP and DNA. The mechanism of AMP damage and DNA cleavage caused by the molybdenum series is mainly oxidation and the oxidation sites are on the ribose parts other than on the adenine parts, while the hydrolysis probably makes significant contributions to the cleavage of DNA and to the damage of AMP caused by the tungsten series.

Key words: Polyoxometalate, DNA cleavage, Nucleotide, AMP, Keggin

PENG Jun, LI Wen-zhuo, ZHAO Xian-ling, HAN Zhan-gang, HUANG Bai-qu. Studies on Model Interaction of Keggin-type Polyoxometalates with Nucleic Acid[J]. Chemical Research in Chinese Universities, 2004, 20(1): 6-9.

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Studies on Model Interaction of Keggin-type Polyoxometalates with Nucleic Acid

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