A Novel Ratiometric Fluorescent Probe for Cyanide Anion with High Selectivity and Its Application in Cell Imaging

doi:10.1007/s40242-017-7036-7

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (4): 534-539.doi: 10.1007/s40242-017-7036-7

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A Novel Ratiometric Fluorescent Probe for Cyanide Anion with High Selectivity and Its Application in Cell Imaging

FENG Yusha^1,2, BAI Lifei³, WANG Shaodan², KONG Xiangyi¹, CONG Lele¹, ZHAO Qing¹, YANG Qingbiao², LI Yaoxian²

1. Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130031, P. R. China;
2. College of Chemistry, Jilin University, Changchun 130021, China;
3. Jiangsu Key Laboratory of Biofunction Molecule, College of Life Science and Cheimistry & Chemical Engineering, Jiangsu Second Normal University, Nanjing 210013, P. R. China

Received:2017-01-20 Revised:2017-03-17 Online:2017-08-01 Published:2017-05-23
Contact: ZHAO Qing E-mail:qingzhao888@hotmail.com
Supported by:
Supported by the Jilin Province Science and Technology Research Plan，China（No.20170204039GX）.

Abstract

Abstract:

A novel hybrid acenaphthene-hemicyanine dye(Acc) was designed and synthesized as a colorimetric and ratiometric fluorescent sensor for cyanide detection. The nucleophilic addition of cyanide anion resulted in the blocking of the intramolecular charge transfer(ICT). Thus, the sensor exhibited high sensitivity and selectivity t owards cyanide anion among many anions in dimethylsulphoxide(DMSO)-water media, with the emission wavelength displaying a very large shift(186 nm). Moreover, the color changes of the solution could be observed by the naked eyes and it had a short response time. Under optimized conditions, the detection limit for cyanide was calculated to be 1.3 μmol/L(R²=0.9958). In addition, the probe had excellent biocompatibility and could be utilized to monitor cyanide in living cells.

Key words: Ratiometric fluorescence, Cyanide, Nucleophilic addition, Bioimaging

FENG Yusha, BAI Lifei, WANG Shaodan, KONG Xiangyi, CONG Lele, ZHAO Qing, YANG Qingbiao, LI Yaoxian. A Novel Ratiometric Fluorescent Probe for Cyanide Anion with High Selectivity and Its Application in Cell Imaging[J]. Chemical Research in Chinese Universities, 2017, 33(4): 534-539.

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A Novel Ratiometric Fluorescent Probe for Cyanide Anion with High Selectivity and Its Application in Cell Imaging

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