Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

doi:10.1007/s40242-015-5060-z

Chemical Research in Chinese Universities ›› 2015, Vol. 31 ›› Issue (3): 401-405.doi: 10.1007/s40242-015-5060-z

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Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

YANG Shuang¹, GUO Zhihua¹, YANG Xuewei¹, XIE Jing¹, Robert J. LEE^1,2, JIANG Dan¹, TENG Lesheng¹

1. College of Life Sciences, Jilin University, Changchun 130012, P. R. China;
2. College of Pharmacy, The Ohio State University, Columbus 43210, USA

Received:2015-02-11 Revised:2015-03-31 Online:2015-06-01 Published:2015-04-13
Contact: TENG Lesheng E-mail:tenglesheng@jlu.edu.cn
Supported by:
Supported by the Open Project of the State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, China.

Abstract

Abstract:

We described a novel approach for survivin siRNA cellular delivery via a cationic liposome incorporating fatty acid-modified polyethylenimine. A linoleic acid derivative of branched polyethylenimine(PEI, M_w=25 kDa), PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEI-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently compared with PEI-25kDa.

Key words: Polyethylenimine, siRNA, Survivin, Cationic liposome, Cancer

YANG Shuang, GUO Zhihua, YANG Xuewei, XIE Jing, Robert J. LEE, JIANG Dan, TENG Lesheng. Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine[J]. Chemical Research in Chinese Universities, 2015, 31(3): 401-405.

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Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

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