CRCU

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (3): 603-606.doi: 10.1007/s40242-013-2373-7

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Synthesis, Micellization and Characterization of Novel Amphiphilic β-Cyclodextrin/Poly(L-aspartate) Copolymer

GUO Yan-ling1, CUI Zhao-shan2, HAN Min2   

  1. 1. College of Science, Tianjin University of Science and Technology, Tianjin 300457, P. R. China;
    2. College of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, P. R. China
  • Received:2012-09-25 Revised:2012-10-29 Online:2013-06-01 Published:2013-05-15
  • Supported by:

    Supported by the Fund of the Key Laboratory of Tianjin Biomedical Materials, China(No.2011-116-1).

Abstract:

A novel amphiphilic β-cyclodextrin/poly(L-aspartate)(β-CD-PASP) copolymer was prepared by ring- opening polymerization of polysuccinimide(PSI). This copolymer bears β-CD units along the macromolecular chain and the structure was characterized by infrared(IR) and proton nuclear magnetic resonance(1H NMR). The molecular weight of the copolymer was determined by gel permeation chromatography(GPC). The copolymer micelle were prepared by direct dissolution method. The critical micelle concentration(CMC) of the copolymer micelle was mea- sured by flourescence technique with pyrene as probe. The size distribution of micelle was characterized on a dynamic laser light scattering particle size analyzer and its shape was observed by transmission electron microscopy(TEM). The results show that the copolymer could self-assemble into micelle with a low CMC, and the effective diameter of the micelle was 116.3 nm. The methotrexate(MTX)-loaded micelle were prepared and the drug loading content(DLC) was 22.86%. The MTX-loaded copolymer exhibited a better water-solubility than the free drug.

Key words: β-Cyclodextrin, Amphiphilic, Micellization, Methotrexate