Controlled Release of Curcumin via Folic Acid Conjugated Magnetic Drug Delivery System

doi:10.1007/s40242-018-7293-0

Abstract

Abstract: In the paper, folic acid(FA)-mediated and β-cyclodextrin(β-CD) derivatives functionalized magnetic Fe₃O₄ nanoparticles(MNPs) were successfully prepared as drug carriers for the targeted delivery and controlled release of water-insoluble anticancer drug. FA-sulfobutyl ether-β-CD-MNPs(FA-SBE-β-CD-MNPs), FA-hydroxypropyl-β-CD-MNPs(FA-HP-β-CD-MNPs) and FA-carboxymethyl-β-CD-MNPs(FA-CM-β-CD-MNPs) were fabricated, and the loading efficiency and relative entrapment rate of curcumin are 12.04 mg/g, 95.56% for FA-SBE-β-CD-MNPs, 9.6 mg/g, 81.63% for FA-HP-β-CD-MNPs and 7.88 mg/g, 85.28% for FA-CM-β-CD-MNPs, respectively. Meanwhile, at pH=5.0, the optimal release rate of curcumin is about 46.07% for FA-SBE-β-CD-MNPs in 5 h. Cellular uptake indicates that curcumin can be selectively transported to targeting site and released from the internalized carriers. The in vitro cytotoxicity reveals that non-toxic FA-SBE-β-CD-MNPs have excellent biocompatibility on HepG2 cells in the tested concentrations. Therefore, FA-SBE-β-CD-MNPs could provide a promising platform for the targeting delivery of water insoluble anti-cancer drugs for different treatment needs of cancer therapy.

Key words: Folic acid, β-Cyclodextrin, Anti-cancer drug, Targeted delivery, Magnetic nanoparticle

SONG Shengmei, LI Minglu, GONG Xiaojuan, HAN Hui, ZHOU Yehong, WANG Li, SHUANG Shaomin, DONG Chuan. Controlled Release of Curcumin via Folic Acid Conjugated Magnetic Drug Delivery System[J]. Chemical Research in Chinese Universities, 2018, 34(2): 203-211.

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