Electrochemical Method to Characterize Multidrug Resistance

doi:10.1007/s40242-014-4153-4

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3): 437-440.doi: 10.1007/s40242-014-4153-4

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Electrochemical Method to Characterize Multidrug Resistance

LU Shan¹, NING Limin², GAO Tao², WU Xiaolan², YIN Yongmei¹, LI Genxi^2,3

1. Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;
2. State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China;
3. Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Received:2014-04-24 Revised:2014-05-04 Online:2014-06-01 Published:2014-05-12
Contact: YIN Yongmei, LI Genxi E-mail:ym.yin@hotmail.com;genxili@nju.edu.cn
Supported by:
Supported by the National Science Fund for Distinguished Young Scholars of China(No.20925520) and the National Natural Science Foundation of China(Nos.21235003, 81172503).

Abstract

Abstract:

Multidrug resistance(MDR) is a main factor to make the failure of chemotherapy. It is closely related to the over-expression of P-glycoprotein(P-gp), multidrug resistance protein(MRP) and breast cancer resistance protein(BCRP). Herein we reported a novel method to characterize MDR, taking advantage of the electrochemical pro- perty of chemotherapeutic drugs. Meanwhile, the definition of accumulation phase and retention phase has been improved. Furthermore, with specific modulators introduced to inhibit the relevant efflux pumps, the exact protein that mainly works in the cells employed in this study can be identified.

Key words: Multidrug resistance, Mitoxantrone, Drug efflux, Electrochemistry

LU Shan, NING Limin, GAO Tao, WU Xiaolan, YIN Yongmei, LI Genxi. Electrochemical Method to Characterize Multidrug Resistance[J]. Chemical Research in Chinese Universities, 2014, 30(3): 437-440.

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