An Efficient and Green Approach to Synthesizing Enamines by Intermolecular Hydroamination of Activated Alkynes

doi:10.1007/s40242-015-4388-8

Abstract

Abstract:

An efficient, atom-economic and green approach to synthesizing enamines was developed by intermolecular hydroamination of activated alkynes with high yields under catalyst- and solvent-free conditions. β-Dimethylamino-acrylate derivatives were also obtained with high yields. In the synthetic process of the derivatives, N,N-dimethylformamide(DMF) pretreated with metal Na, was used as reactant instead of dimethylamine gas. The proposed synthetic method can be used for the synthesis of (E)-ethyl-3-(dimethylamino)acrylate(3cl), and provide a new possible way to the synthesis of Quinolones.

Key words: Enamine, Hydroamination, Activated alkyne, Catalyst-free, Solvent-free, N,N-Dimethylformamide

ZENG Ruijie, SHENG Hongting, RAO Bo, FENG Yan, WANG Hao, SUN Yehua, CHEN Man, ZHU Manzhou. An Efficient and Green Approach to Synthesizing Enamines by Intermolecular Hydroamination of Activated Alkynes[J]. Chemical Research in Chinese Universities, 2015, 31(2): 212-217.

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