CRCU

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (3): 410-414.

• Articles • Previous Articles     Next Articles

Development and Characterization of an Electrochemical Sensor for Cinchonidine Detection Based on Molecularly Imprinted Polymer with Modified Rosin as Cross-linker

LIU Li1, TAN Xue-cai1,2,3, ZHAO Dan-dan1, WANG Lin1, LEI Fu-hou1,2, HUANG Zai-yin1   

  1. 1. School of Chemistry and Ecological Engineering, Guangxi University for Nationalities, Nanning 530008, P. R. China;
    2. Guangxi Key Laboratory of Chemistry and Engineering of Forest Produts, Guangxi University for Nationalities, Nanning 530008, P. R. China;
    3. Key Laboratory of Chemical and Biological Transforming Process, Guangxi University, Nanning 530008, P. R. China
  • Received:2011-06-20 Revised:2011-10-20 Online:2012-05-25 Published:2012-05-03
  • Contact: TAN Xue-cai E-mail:xctan@yahoo.cn
  • Supported by:

    Supported by the National Nature Science Foundation of China(Nos.21065001 and 30960306), the Natural Science Foundation of Guangxi Province, China(Nos.0639025, 0991084 and 0991001z), the Fund of Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, China(No.GXFC08-06), the Project of Education Department of Guangxi Province, China( No.200812MS074) and the Innovation Project of Guangxi University for Nationalities, China(No.gxun-chx2011086).

PDF (PC)

Abstract: Molecularly imprinted polymers(MIPs) were applied as molecular recognition elements to an electrochemical sensor for cinchonidine(CD). A kind of MIP was synthesized with cinchonidine as template, modified rosin( ethylene glycol maleic rosinate acrylate) containing the skeleton of phenanthrene rings as cross-linker and methylacrylic acid as functional monomer. MIP membrane was prepared on a glassy carbon electrode for the determination of CD via free radical polymerization method. Electrochemical impedance spectroscopy(EIS) and cyclic voltammetry( CV) were used to characterize the membrane electrochemical behavior in electrode fabrication process. The experimental conditions were discussed. Under optimum conditions, it was found that the response of peak currents was linear to the concentration of CD in a range of 0.013―2.26 mmol/L. The detection limit for CD is 1 μmol/L, the relative standard deviation for 100 μmol/L CD is 1.34% and the incubation time is 2 min. The sensor was applied to the determination of CD in urine samples with satisfactory results.

Key words: Ethylene glycol maleic rosinate acrylate, Cinchonidine, Molecularly imprinted polymer, Electrochemical sensor