RGDC Peptide Modified Quantum Dots Labelling and Imaging of Tumor Cells

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (5): 832-835.

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RGDC Peptide Modified Quantum Dots Lablling and Imaging in Tumour Cells

GUO Yi¹, LI Chun-rong¹, SHEN Huai-bin³, ZHANG Xue-zhong¹, LI Lin-song^3*, YU Qian^2* and XU Li^1*

1. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. Department of Drug Administration, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
3. Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng 475004, P. R. China

Received:2011-01-25 Revised:2011-04-22 Online:2011-09-25 Published:2011-09-06
Contact: XU Li;YU Qian;LI Lin-song E-mail:xuli@jlu.edu.cn; yuq_zrly@yahoo.com.cn; linsli21@yahoo.com
Supported by:
Supported by the National Natural Science Foundation of China(Nos.30970719, 21043002), the Social Development Project of Science and Technology Department of Jilin Province, China(Nos.20106031, 20090133), the Project of Science and Techno- logy Department of Changchun City, China(No.09SF02) and the Fundamental Research Funds of Jilin University, China (No.200903098).

Abstract

Abstract: The labelling and imaging of tumor cells were investigated via arginine-glycine-aspartic acid- cysteine(RGDC) peptide-labelled quantum dots(QDs). The results show that RGDC modified QDs can label SMMC-7721 tumor cells and adhere to cellular membrane. In constrast, the unmodified QDs are mainly dispersed around the cell. We also found that the RGDC-QDs can penetrate into the cell at 2 h of incubation. After 6 h of incubation, RGDC-QDs can accumulate in a unique intracellular region.

Key words: Arginine-glycine-aspartic acid-cysteine(RGDC) peptide, Quantum dot, Fluorescence labelling

GUO Yi, LI Chun-rong, SHEN Huai-bin, ZHANG Xue-zhong, LI Lin-song*, YU Qian* and XU Li*. RGDC Peptide Modified Quantum Dots Lablling and Imaging in Tumour Cells[J]. Chemical Research in Chinese Universities, 2011, 27(5): 832-835.

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RGDC Peptide Modified Quantum Dots Lablling and Imaging in Tumour Cells

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