Chemical Research in Chinese Universities ›› 2010, Vol. 26 ›› Issue (6): 937-941.

• Articles • Previous Articles     Next Articles

Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

CHEN Jiao, MA Zhen and YAN Chao-guo*   

  1. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China
  • Received:2009-12-14 Revised:2010-08-16 Online:2010-11-25 Published:2010-12-01
  • Contact: YAN Chao-guo E-mail:cgyan@yzu.edu.cn
  • About author:YAN Chao-guo. E-mail: cgyan@yzu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20972132).

Abstract: The three-component reaction of aromatic aldehyde, malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines, 2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used. 

Key words: Multicomponent reaction, Malononitrile, Aldehyde, Dihydropyridine, Pyridine, Aminopyridine