CRCU

Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (1): 32-35.

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Polarographic Studies on Associations of Midecamycin and Chloroquine with Hydrogen Peroxide

LI Ning1, SONG Jun-feng1, XU Mao-tian1, ZHANG Ya2   

  1. 1. Institute of Analytical Science, Northwest University, Xi′an 710069, P. R. China;
    2. Department of Chemistry, Suide Teachers′ School, Suide 718000, P. R. China
  • Received:2003-12-14 Online:2005-01-24 Published:2011-07-27
  • Supported by:

    Supported by the National Natural Science Foundation of P.R.China(No.20475043) and the Natural Science Foundation of Shaanxi Province(No.2002B01).

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Abstract: The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography.In a 0.15 mol/L KH2PO4-NaOH(pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1∶1, and the apparent association constant is 7.18.While in a 0.04 mol/L NH3·H2O-NH4Cl(pH 9.5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1∶1 and 45.4, respectively.The formation of the association complexes stabilizes H2O2 and results in the accumulation of H2O2, which is baneful to human body.

Key words: Midecamycin, Chloroquine phosphate, Hydrogen peroxide, Association, Linear-potential scan polarography, Reactive oxygen species